Multi-cellular movements are found in various phenomena such as embryogenesis, cancer diseases, wound healing, and metabolism. While key genes and proteins differ by phenomenon, multicellular movements commonly follow mechanics. What are the mechanics that govern multicellular movement?
In the shaping of living organisms, individual cells interact in a multimordal way. To understand the complex phenomenon, we combine stem cell organoid experiments reproducing 3D structures of embryonic tissues in vitro, mechanics-based simulations predicting 3D cell dynamics, and so on.
Our approach integrates microscopic behaviors found at the molecular and cellular levels to predict the macroscopic shaping at the tissue and organ levels. In the bottom-up manner, we aim to provide a comprehensive understanding of multicellular system across a wide range of scales as a single system.
This laboratory newly started from April 2019. We are looking for master and doctoral students, and postdocs to work together. Please contact us if you want to know the latest information. →RECRUITMENT
By combining stem cell organoid culture experiments and computational simulations, we have elucidated the mechanics in morphogenesis. We have elucidated the mechanisms by which the deformation of the entire tissue feeds back to the force generation of individual cells.→FEEDBACK
To analyze multicellular dynamics in 3D space, we have developed a general-purpose 3D vertex model that describes the 3D dynamics of tissues at a single cell resolution. The high versatility of this model makes it possible to quantitatively analyze various multicellular dynamics in development and diseases.→3DVERTEX
Okuda Lab, Nano Life Science Institute,
Kakuma-machi, Kanazawa 920-1192, Japan
Nano Life Science Institute, 4F, Room 403
satokuda AT staff.kanazawa-u.ac.jp